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Image Search Results
Journal: AJNR: American Journal of Neuroradiology
Article Title: A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging
doi: 10.3174/ajnr.A5896
Figure Lengend Snippet: Perfusion, structural, and histology images from a mouse injected with the nanoparticles. The parameters were the following: FOV = 4 cm, 35 projections, best image quality, Lodespin scan mode. A 70- to 100- L intravenous bolus of iron nanoparticles (0.949 mg Fe/mL; core diameter, 27.6 nm) donated by Dr Kannan Krishnan, University of Washington, was administered to C57Bl/6 stroke mice through tail veins. The mice were sacrificed within 30 minutes postinjection, and 3D-MPI was performed using a MOMENTUM MPI system. Anatomic images were collected on the eXplore CT-120 microCT (GE Healthcare, Milwaukee, Wisconsin) and a 7T MR imaging scanner (BioSpec; Bruker Instruments, Billerica, Massachusetts). Data analysis and image registration were performed using the Horos (https://sourceforge.net/projects/horos/) and VivoQuant software (Invicro, Boston, Massachusetts). In vivo iron oxide quantification was performed by imaging fiducials containing a known concentration of tracer positioned beside the animal. A, In the 2D coregistered image from CT and MPI, the MPI signal (red if high, yellow if intermediate, blue if low) from the left hemisphere is less than that from the contralateral side (red spots indicate vascular structures with high blood volume). B, The high T2 signal (stroke lesion, arrowheads) in the left basal ganglia and thalamus. C, The histology image of a perfusion-fixed whole brain shows the stroke lesion on the left (L). R indicates right.
Article Snippet: Data analysis and image registration were performed using the
Techniques: Injection, Imaging, Software, In Vivo, Concentration Assay
Journal: AJNR: American Journal of Neuroradiology
Article Title: A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging
doi: 10.3174/ajnr.A5896
Figure Lengend Snippet: SPION-labeled macrophages have long retention times in the brain of a stroke mouse. We administered 1–2 × 106 nanoparticle (VivoTrax; Magnetic Insight)-labeled mouse macrophages (Raw 264.7; American Type Culture Collection, Manassas, Virginia) to BALB/c mice through tail veins 24 hours after stroke. At 48, 72, and 96 hours poststroke, 2D-MPI was performed using a MOMENTUM MPI system. The MPI protocol used the parameters of FOV = 4 cm, 55 projections, best image quality, and default scan mode. Anatomic images were collected on the eXplore CT-120 microCT. Data analysis and image registration were performed using the Horos and VivoQuant software. In vivo iron oxide quantification was performed by imaging a fiducial containing a known concentration of tracer positioned beside the animal. The MPI signal was detected in the brain at 48, 72, and 96 hours poststroke; the accumulation of iron-labeled cells was the highest at 48 hours and reduced with time.
Article Snippet: Data analysis and image registration were performed using the
Techniques: Labeling, Software, In Vivo, Imaging, Concentration Assay